Monday, October 31, 2011

Judge rejects both Tribune bankruptcy plans (Reuters)

NEW YORK (TheWrap.com) ? U.S. bankruptcy judge Kevin J. Carey has rejected Tribune Co.'s plan for reorganizing the company so that it can emerge from bankruptcy. A rival proposal from Tribune creditors did not pass muster either.

Carey, a judge in the U.S. Bankruptcy Court in Delaware, on Monday issued an order directing Tribune and its creditors to come up with another plan quickly. The next hearing is set for November 22.

Tribune, a media empire that includes newspapers like the Los Angeles Times and Chicago Tribune, as well as more than 20 broadcasting properties, filed for Chapter 11 bankruptcy in December of 2008. That came a year after real-estate tycoon Sam Zell took the company private.

Tribune has issued the following statement: "We are reviewing the judge's decision and will have no comment until we have finished studying it."

Carey began his 126-page opinion with a story, "The Scorpion and the Fox." He said there is no moral to it, but that it reveals an "inescapable facet of human character: the willingness to visit harm upon others, even at one's own peril."

He then detailed the many ways in which neither plan could settle a dispute that is now almost three years old, and threatened to appoint a trustee to resolve the case if neither side can reach a suitable resolution.

Under both plans, JP Morgan and other lenders would be the majority owners.

Source: http://us.rd.yahoo.com/dailynews/rss/enindustry/*http%3A//news.yahoo.com/s/nm/20111101/media_nm/us_tribune

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Hollywood studio defends filming in Chinese city

FILE - In this undated file photo released by his supporters, blind activist Chen Guangcheng, right sits in a village in China. Rights activists have criticized a Hollywood studio for filming a buddy comedy in an eastern Chinese city where the blind, self-taught activist lawyer is being held under house arrest and reportedly beaten. Relativity Media is shooting part of the comedy "21 and Over" in Linyi, a city in Shandong province where the activist Chen's village is located. Authorities have turned Chen's village of Dongshigu into a hostile, no-go zone and activists, foreign diplomats and reporters have been turned back, threatened and had stones thrown at them by men patrolling the village. (AP Photo/Supporters of Chen Guangcheng, File)

FILE - In this undated file photo released by his supporters, blind activist Chen Guangcheng, right sits in a village in China. Rights activists have criticized a Hollywood studio for filming a buddy comedy in an eastern Chinese city where the blind, self-taught activist lawyer is being held under house arrest and reportedly beaten. Relativity Media is shooting part of the comedy "21 and Over" in Linyi, a city in Shandong province where the activist Chen's village is located. Authorities have turned Chen's village of Dongshigu into a hostile, no-go zone and activists, foreign diplomats and reporters have been turned back, threatened and had stones thrown at them by men patrolling the village. (AP Photo/Supporters of Chen Guangcheng, File)

(AP) ? A Hollywood studio on Monday defended its decision to film part of a buddy comedy in a Chinese city where a blind activist is being held under house arrest, saying it advocates human rights and that engaging China in business could bring positive results.

Relativity Media is shooting part of the comedy, "21 and Over," in Linyi, a city in Shandong province where the activist Chen Guangcheng's village is located. Authorities have turned Chen's village of Dongshigu into a no-go zone, where activists, foreign diplomats and reporters have been turned back and threatened.

Rights activists have criticized Relativity's choice of Linyi as a location and the way it touted its close government connections in a press release last week.

Relativity said Monday in an emailed statement: "From its founding, Relativity Media has been a consistent and outspoken supporter of human rights and we would never knowingly do anything to undermine this commitment."

Relativity said it was also proud of its growing business relationships in China. In August, Relativity said that it will distribute future films in China through a joint venture called Sky Land, which it owns with two other companies. Sky Land recently announced an alliance with one of the Chinese government's official film distribution agencies, Huaxia Film Distribution Company.

"As a company, we believe deeply that expanding trade and business ties with our counterparts in China and elsewhere can result in positive outcomes," Relativity said.

The incident points to the potential risks of engaging with the Chinese government to improve one's chances of tapping into one of the movie industry's most coveted yet most inaccessible markets.

Hollywood studios operating in China have been frustrated for years by a de facto quota of 20 foreign blockbusters a year.

Relativity describes "21 and Over" as a comedy about two childhood friends who drag their buddy out to celebrate his 21st birthday.

___

Follow Gillian Wong on Twitter at http://twitter.com/gillianwong

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2011-10-31-AS-China-Blind-Lawyer/id-66ceadfd3fd44376b9ef7b6efddad5e1

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At Democratic meeting, Biden blames GOP for country's woes (tbo)

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Sunday, October 30, 2011

Studies challenge wisdom of GOP candidates' plans (AP)

WASHINGTON ? Key proposals from the Republican presidential candidates might make for good campaign fodder. But independent analyses raise serious questions about those plans and their ability to cure the nation's ills in two vital areas, the economy and housing.

Consider proposed cuts in taxes and regulation, which nearly every GOP candidate is pushing in the name of creating jobs. The initiatives seem to ignore surveys in which employers cite far bigger impediments to increased hiring, chiefly slack consumer demand.

"Republicans favor tax cuts for the wealthy and corporations, but these had no stimulative effect during the George W. Bush administration, and there is no reason to believe that more of them will have any today," writes Bruce Bartlett. He's an economist who worked for Republican congressmen and in the administrations of Presidents Ronald Reagan and George H.W. Bush.

As for the idea that cutting regulations will lead to significant job growth, Bartlett said in an interview, "It's just nonsense. It's just made up."

Government and industry studies support his view.

The Bureau of Labor Statistics, which tracks companies' reasons for large layoffs, found that 1,119 layoffs were attributed to government regulations in the first half of this year, while 144,746 were attributed to poor "business demand."

Mainstream economic theory says governments can spur demand, at least somewhat, through stimulus spending. The Republican candidates, however, have labeled President Barack Obama's 2009 stimulus efforts a failure. Instead, most are calling for tax cuts that would primarily benefit high-income people, who are seen as the likeliest job creators.

"I don't care about that," Texas Gov. Rick Perry told The New York Times and CNBC, referring to tax breaks for the rich. "What I care about is them having the dollars to invest in their companies."

Many existing businesses, however, have plenty of unspent cash. The 500 companies that comprise the S&P index have about $800 billion in cash and cash equivalents, the most ever, according to the research firm Birinyi Associates.

The rating firm Moody's says the roughly 1,600 companies it monitors had $1.2 trillion in cash at the end of 2010. That's 11 percent more than a year earlier.

Small businesses rate "poor sales" as their biggest problem, with government regulations ranking second, according to a survey by the National Federation of Independent Businesses. Of the small businesses saying this is not a good time to expand, half cited the poor economy as the chief reason. Thirteen percent named the "political climate."

More small businesses complained about regulation during the administrations of Bill Clinton and George H.W. Bush, according to an analysis of the federation's data by the liberal Economic Policy Institute.

Such findings notwithstanding, further cuts in taxes and regulations remain popular with GOP voters. A recent Associated Press-GfK poll found that most Democrats and about half of independents think "reducing environmental and other regulations on business" would do little or nothing to create jobs. But only one-third of Republicans felt that way.

The GOP's presidential hopefuls are shaping their economic agendas along those lines.

Former Massachusetts Gov. Mitt Romney says his 59-point plan "seeks to reduce taxes, spending, regulation and government programs."

Businessman Herman Cain would significantly cut taxes for the wealthy with his 9 percent flat tax plan. Rep. Michele Bachmann of Minnesota said in a recent debate, "It's the regulatory burden that costs us $1.8 trillion every year. ... It's jobs that are lost."

The candidates have said little about another national problem: depressed home prices, as well as the high numbers of foreclosures and borrowers who owe more than their houses are worth.

After the Oct. 18 GOP debate in Las Vegas, a center of foreclosure activity, editors of the AOL Real Estate site wrote, "We didn't hear any meaningful solutions to the housing crisis. That's no surprise, considering that housing has so far been a ghost issue in the campaign."

To the degree the candidates addressed housing, they mainly took a hands-off approach. "We need to get government out of the way," Cain said. "It starts with making sure that we can boost this economy and then reform Dodd-Frank," which is a law that regulates Wall Street transactions.

Bachmann, in an answer that mentioned "moms" six times, said foreclosures fall most heavily on women who are "losing their nest for their children and for their family." She said Obama "has failed you on this issue of housing and foreclosures. I will not fail you on this issue." Bachmann offered no specific remedies.

Romney told editors of the Las Vegas Review-Journal: "Don't try and stop the foreclosure process. Let it run its course and hit the bottom. Allow investors to buy homes, put renters in them, fix the homes up and let it turn around and come back up."

Perry spokesman Mark Miner said the Texas governor's "immediate remedy for housing is to get America working again. ... Creating jobs will address the housing concerns that are impacting communities throughout America."

Bartlett, whose books on tax policy include "The Benefit and the Burden," recently wrote in the New York Times: "People are increasingly concerned about unemployment, but Republicans have nothing to offer them."

The candidates and their supporters dispute this, of course. A series of scheduled debates may give them chances to explain why their proposals would hit the right targets.

Source: http://us.rd.yahoo.com/dailynews/rss/politics/*http%3A//news.yahoo.com/s/ap/20111030/ap_on_bi_ge/us_republicans_questionable_policies

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NATO: 30 insurgents killed in eastern Afghanistan

Insurgents attacked a convoy of Afghan and international troops on Friday in eastern Afghanistan, starting a firefight that left about 30 of the attacking militants dead, NATO said.

The joint Afghan-international force called for air support during the gunbattle in Shinwar district of Nangarhar province, the U.S.-led coalition in Afghanistan said. No other information was disclosed and it is unclear whether any Afghan or coalition forces were killed or wounded.

NATO forces in Afghanistan have concentrated on Taliban strongholds in southern Afghanistan in the past several years, but more recently have shifted their focus to the east along the border with Pakistan.

In the south, a NATO service member was killed in a roadside bombing in the same restive province where the U.S.-led alliance, a day earlier, had repelled a coordinated Taliban attack on a U.S.-run civilian and military base.

The service member died as a result of an improvised explosive device in Kandahar province, the Taliban's traditional stronghold, NATO said in a statement that did not provide additional details. The death raises to 480 the number of coalition forces killed in Afghanistan so far this year.

Earlier, the U.S.-led alliance said its troops, in tandem with Afghan police, repulsed on Thursday a Taliban attack on a camp in Kandahar that is home to NATO troops, including Americans, and a provincial reconstruction team.

NATO said one Afghan interpreter was killed in the attack that began at 2:30 p.m., while one American civilian contractor and two Afghan security guards were injured. In addition, five NATO service members were slightly wounded, the alliance said.

The attack began as the Taliban launched an assault from a compound across from the camp, firing rocket-propelled grenades and small arms fire, NATO said. Coalition forces returned fire while Afghan police, led by Kandahar provincial Police Chief Gen. Abdul Razzaq who was at the base at the time of the attack for a meeting, began clearing the compound.

Two car bombs went off as the Afghan police were clearing the compound, NATO said, but there were no injuries as a result of the explosions. The buildings had been rigged with improvised explosives devices and NATO forces, at the request of Afghan officials, "used precision munitions to reduce the threat," the coalition said.

On Thursday, Razzaq had said that two of the attackers were killed as forces cleared the compound.

Kandahar, and much of the south, had long been seen as a Taliban stronghold, but Afghan and coalition forces have made significant gains in the area and the insurgents have since shifted their operations further east and to some northern provinces.

NATO said the presence of car bombs at the site indicated the insurgents had a plan, which they were unable to execute, and that it had expected the Taliban to launch such an attack before the onset of winter, when the violence and attacks tend to abate.

In other incidents across the country, a civilian car struck a roadside bomb early Friday in Nangarhar province's Khogyani district, killing two men, a woman and a child, said district chief Mohammad Hassan.

Copyright 2011 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://www.msnbc.msn.com/id/45079379/ns/world_news-south_and_central_asia/

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Where to Find Free Music and Spooky Sounds for Your Halloween Party [Halloween]

Where to Find Free Music and Spooky Sounds for Your Halloween PartyIf you need free music for your party we have you covered whether you need rock, classical, or kid's music.

Free Downloads from the Web

About.com's Digital Music section has a great selection of free Halloween songs and sound effects. Here are a few gems:

  • Calling All Fiends is a compilation of atmospheric tracks from a variety of artists. If you want your house to sound like an episode of Angel, this is the one to grab.
  • SoundBible has a list of 40 or so Halloween sound effects downloadable as mp3 or wav files such as "Scary Demon Haunting" and "Zombie on the Loose".
  • Halloween Music for Kids has 10 free themed kids tracks you've never heard of but aren't bad.

Spotify

Spotify users can rest easy?there are many existing Halloween-themed playlists. Here are a few recommended ones:

  • Spotify's Official Halloween Playlist contains a few standards like Thriller and Ghostbusters but has a few dubious choices like the version of Clair de Lune used in Twilight.
  • Haunted House 101 is full of cheesy and creepy sound effects; screams, wolves howling, heartbeats, and all the other usual suspects. (16 tracks, 26 minutes)
  • Halloween Rocks 2011 is a mix of classic rock with a touch of metal, blues, ska, and r&b that should please most people who want Halloween-themed songs but not novelty songs like Monster Mash. (44 tracks, 2 hours)
  • Collaboowean 2011 created by our own Adam Pash and full of the nerdcore stuff like Jonathan Coulton and Voltaire. (currently 110 tracks, 7 hours)

Pandora

Earlier in the month Pandora created a Halloween genre with eight stations: Halloween Party, Children's Hallowen, Halloween, Spooky Symphonies, Industrial, Goth, Ghostly Grooves, and Witch House.

What are your favorite Halloween-themed songs? Let us know in the comments below. Photo by infrogmation.

Free Halloween Music About.com

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/bdDcQQ2fy94/where-to-find-free-music-and-spooky-sounds-for-your-halloween-party

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Saturday, October 29, 2011

Pythons' big hearts hold clues for human health

This undated handout photo provided by the journal Science shows an adult Burmese python. You don't think of pythons as big-hearted toward their fellow creatures. They're better known for the bulge in their bodies after swallowing one of those critters whole. But the snakes' hearts balloon in size, too, as they're digesting _ and now scientists are studying them for clues about human heart health. (AP Photo/Stephen M. Secor, Science)

This undated handout photo provided by the journal Science shows an adult Burmese python. You don't think of pythons as big-hearted toward their fellow creatures. They're better known for the bulge in their bodies after swallowing one of those critters whole. But the snakes' hearts balloon in size, too, as they're digesting _ and now scientists are studying them for clues about human heart health. (AP Photo/Stephen M. Secor, Science)

(AP) ? You don't think of pythons as big-hearted toward their fellow creatures. They're better known for the bulge in their bodies after swallowing one of those critters whole.

But the snakes' hearts balloon in size, too, as they're digesting ? and now scientists are studying them for clues about human heart health.

The expanded python heart appears remarkably similar to the larger-than-normal hearts of Olympic-caliber athletes. Colorado researchers report they've figured out how the snakes make it happen.

"It's this amazing biology," said Leslie Leinwand, a molecular biologist at the University of Colorado Boulder, whose team reports the findings in Friday's edition of the journal Science. "They're not swelling up. They're building (heart) muscle."

Reptile biologists have long studied the weird digestion of these snakes, especially the huge Burmese pythons that can go nearly a year between meals with no apparent ill effects. When they swallow that next rat or bird ? or in some cases deer ? something extraordinary happens. Their metabolism ratchets up more than 40-fold, and their organs immediately start growing in size to get the digesting done. The heart alone grows a startling 40 percent or more within three days.

Leinwand, who studies human heart disease, stumbled across that description and saw implications for people. An enlarged human heart usually is caused by chronic high blood pressure or other ailments that leave it flabby and unable to pump well. But months and years of vigorous exercise give some well-conditioned athletes larger, muscular hearts, similar to how python hearts are during digestion.

So Leinwand's team ? led by a graduate student who initially was frightened of snakes ? ordered a box of pythons and began testing what happens to their hearts.

The first surprise: A digesting python's blood gets so full of fat it looks milky. A type of fat called triglycerides increased 50-fold within a day. In people, high triglyceride levels are very dangerous. But the python heart was burning those fats so rapidly for fuel that they didn't have time to clog anything up, Leinwand said.

The second surprise: A key enzyme that protects the heart from damage increased in python blood right after it ate, while a heart-damaging compound was repressed.

Then the team found that a specific combination of three fatty acids in the blood helped promote the healthy heart growth. If they injected fasting pythons with that mixture, those snakes' hearts grew the same way that a fed python's does.

But did it only work for snakes? Lead researcher Cecilia Riquelme dropped some plasma from a fed python into a lab dish containing the heart cells of rats ? and they grew bigger, too. Sure enough, injecting living mice made their hearts grow in an apparently healthy way as well.

Now the question is whether that kind of growth could be spurred in a mammal with heart disease, something Leinwand's team is starting to test in mice with human-like heart trouble. They also want to know how the python heart quickly shrinks back to its original size when digestion's done.

The experiments are "very, very cool indeed," said James Hicks, a biologist at the University of California, Irvine, who has long studied pythons' extreme metabolism and wants to see more such comparisons.

If the same underlying heart signals work in animals as divergent as snakes and mice, "this may reveal a common universal mechanism that can be used for improving cardiac function in all vertebrates, including humans," Hicks wrote in an email. "Only further studies and time will tell, but this paper is very exciting."

The study was funded by the National Institutes of Health and a Boulder biotechnology company that Leinwand co-founded, Hiberna Corp., that aims to develop drugs based on extreme animal biology.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/b2f0ca3a594644ee9e50a8ec4ce2d6de/Article_2011-10-27-US-MED-Python%20Hearts/id-b974b7fcb889420b81f19251a847809e

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Freese crowns difficult journey to top with MVP award (Reuters)

ST LOUIS (Reuters) ? Local boy David Freese traveled a long road from his high school playing days in the St Louis suburb of Wildwood to reach his destination with a sweep of postseason awards for the comeback kings of baseball.

Overcoming injuries and a delay to his professional path due to burnout, Freese stood tallest among the new Major League Baseball champions by adding World Series MVP honours to his NL Championship Series MVP after the Cardinals' Game Seven win over the Texas Rangers on Friday.

"I've had plenty of days in my life where I thought I wouldn't be even close to being a big leaguer," the 28-year-old third baseman told reporters. "I'm just full of joy, finally."

Freese put his signature on one of the most thrilling World Series games in memory in Thursday's Game Six.

Facing possible elimination, Freese cracked a two-run, two-out triple to right to send the game into extra innings and after St Louis rallied once again with two 10th-inning runs to stay alive, he crushed a walk-off home run in the 11th.

In Friday's winner-takes-all World Series finale, Freese drove a two-run double into the gap in left-center to tie the game 2-2 as the Cards went on to a 6-2 triumph.

"This is definitely a dream come true," he said after hoisting the MVP trophy. "This is incredible."

Freese batted .348 in the series with a home run and seven runs batted in, but his climb to the top was far from easy.

The promising player quit baseball after his days at Lafayette High School, turning down a college baseball scholarship because he felt burned out.

After a year off, Freese realized how much he missed it and entered community college and rekindled his love for the game.

"This is why you keep battling," said Freese, whose Cardinals fought back from a 10- game deficit in the NL Central division to win a playoff berth on the last day of the season.

"Sometimes things don't work out, but you stay on the path."

Drafted by the San Diego Padres in 2006, he spent two seasons in the minor leagues before being traded to his home town team, the Cardinals, where he made his major league debut in 2009.

It was not smooth sailing then either for Freese.

He began 2009 with the Cards but sprained his left ankle and played just 17 games with them.

In 2010, he won the Cardinals starting third base job but suffered injuries to both ankles and required surgery.

This season, he was hitting .356 before he missed 51 games after breaking his left hand when he was hit by a pitch.

He finished the season with a 297 average, 10 homers and 55 RBIs but blossomed in the postseason, winning the NLCS top award after hitting three home runs and driving home nine.

"I think you've got to kind of take a step back and understand all the work you've put into it, and then you realize how many people are the reason why you're here, starting with my folks," he said after the celebrating.

"I quit out of high school, and they were the only two people that supported that decision. If I listened to everybody else, I wouldn't be here right now. No chance."

(Editing by John O'Brien)

Source: http://us.rd.yahoo.com/dailynews/rss/sports/*http%3A//news.yahoo.com/s/nm/20111029/sp_nm/us_baseball_series_freese

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Friday, October 28, 2011

France: No need to extend NATO's Libya mission (AP)

PARIS ? France's defense minister says he doesn't see a need to extend NATO's mission in Libya, now that Moammar Gadhafi is dead and a new government is in charge.

Gerard Longuet says that the international community should still help the new Libyan leadership but with a new mandate, focusing on political instead of military support.

NATO last week announced preliminary plans to wind down the bombing campaign Oct. 31, but then on Wednesday unexpectedly postponed a definitive decision amid continuing consultations with the U.N. and the country's interim government.

Longuet said on France-Info radio Thursday, "I don't exactly understand the need" to keep the operation going. He said the mission is continuing surveillance but is already "being dismantled rather quickly."

Source: http://us.rd.yahoo.com/dailynews/rss/africa/*http%3A//news.yahoo.com/s/ap/20111027/ap_on_re_eu/eu_france_libya

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Nobel Laureate Bruce Beutler on molecular sensors as a trigger for autoimmune disease

Nobel Laureate Bruce Beutler on molecular sensors as a trigger for autoimmune disease [ Back to EurekAlert! ] Public release date: 27-Oct-2011
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Contact: Tracy Kasten
tkasten@liebertpub.com
914-740-2291
Mary Ann Liebert, Inc./Genetic Engineering News

Body's molecular sensors may trigger autoimmune disease findings presented in article coauthored by 2011 Nobel Laureate Bruce Beutler, M.D.

New Rochelle, NY, October 27, 2011Bruce Beutler, MD, a co-recipient of the 2011 Nobel Prize in Medicine, has coauthored an article describing a novel molecular mechanism that can cause the body to attack itself and trigger an autoimmune disease. The article is published online ahead of print in Journal of Interferon & Cytokine Research, a peer-reviewed journal published by Mary Ann Liebert, Inc. (www.liebertpub.com) and is available free at www.liebertpub.com/jir

In the article, entitled "Intracellular Nucleic Acid Sensors and Autoimmunity," Argyrios Theofilopoulos, Dwight Kono, Bruce Beutler, and Roberto Baccala, The Scripps Research Institute (La Jolla, California), review the scientific evidence that supports the role of molecular sensors located inside cells in the initiation not only of protective and inflammatory immune responses, but also in an autoimmune response. These sensors recognize nucleic acid signatures that may be shared by foreign pathogens and the body's own DNA and RNA.

Dr. Beutler is one of three recipients awarded the Nobel Prize in Physiology and Medicine. He shares half of the prize with Jules Hoffman, PhD for their discoveries related to how the body's immune system fights disease through the activation of an innate immune response. The third recipient, Ralph Steinman, MD, who died before the Nobel Prizes were announced, previously published an article in AIDS Research and Human Retroviruses. Mary Ann Liebert, Inc. congratulates the three winners for the work and contributions to medicine for which they are being recognized.

###

Journal of Interferon & Cytokine Research, led by Co-Editors-in-Chief Ganes C. Sen, PhD, Chairman, Department of Molecular Genetics, Cleveland Clinic Foundation, and Thomas A. Hamilton, PhD, Chairman, Department of Immunology, Cleveland Clinic Foundation, is an authoritative peer-reviewed journal published monthly in print and online that covers all aspects of interferons and cytokines from basic science to clinical applications. Journal of Interferon & Cytokine Research is the Official Journal of the International Society for Interferon and Cytokine Research. Tables of content and a free sample issue may be viewed online at www.liebertpub.com/jir

Mary Ann Liebert, Inc. is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Viral Immunology, AIDS Research and Human Retroviruses, and DNA and Cell Biology. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 70 journals, books, and newsmagazines is available at www.liebertpub.com

Mary Ann Liebert, Inc. 140 Huguenot St., New Rochelle, NY 10801-5215 www.liebertpub.com
Phone: (914) 740-2100 (800) M-LIEBERT Fax: (914) 740-2101


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

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Nobel Laureate Bruce Beutler on molecular sensors as a trigger for autoimmune disease [ Back to EurekAlert! ] Public release date: 27-Oct-2011
[ | E-mail | Share Share ]

Contact: Tracy Kasten
tkasten@liebertpub.com
914-740-2291
Mary Ann Liebert, Inc./Genetic Engineering News

Body's molecular sensors may trigger autoimmune disease findings presented in article coauthored by 2011 Nobel Laureate Bruce Beutler, M.D.

New Rochelle, NY, October 27, 2011Bruce Beutler, MD, a co-recipient of the 2011 Nobel Prize in Medicine, has coauthored an article describing a novel molecular mechanism that can cause the body to attack itself and trigger an autoimmune disease. The article is published online ahead of print in Journal of Interferon & Cytokine Research, a peer-reviewed journal published by Mary Ann Liebert, Inc. (www.liebertpub.com) and is available free at www.liebertpub.com/jir

In the article, entitled "Intracellular Nucleic Acid Sensors and Autoimmunity," Argyrios Theofilopoulos, Dwight Kono, Bruce Beutler, and Roberto Baccala, The Scripps Research Institute (La Jolla, California), review the scientific evidence that supports the role of molecular sensors located inside cells in the initiation not only of protective and inflammatory immune responses, but also in an autoimmune response. These sensors recognize nucleic acid signatures that may be shared by foreign pathogens and the body's own DNA and RNA.

Dr. Beutler is one of three recipients awarded the Nobel Prize in Physiology and Medicine. He shares half of the prize with Jules Hoffman, PhD for their discoveries related to how the body's immune system fights disease through the activation of an innate immune response. The third recipient, Ralph Steinman, MD, who died before the Nobel Prizes were announced, previously published an article in AIDS Research and Human Retroviruses. Mary Ann Liebert, Inc. congratulates the three winners for the work and contributions to medicine for which they are being recognized.

###

Journal of Interferon & Cytokine Research, led by Co-Editors-in-Chief Ganes C. Sen, PhD, Chairman, Department of Molecular Genetics, Cleveland Clinic Foundation, and Thomas A. Hamilton, PhD, Chairman, Department of Immunology, Cleveland Clinic Foundation, is an authoritative peer-reviewed journal published monthly in print and online that covers all aspects of interferons and cytokines from basic science to clinical applications. Journal of Interferon & Cytokine Research is the Official Journal of the International Society for Interferon and Cytokine Research. Tables of content and a free sample issue may be viewed online at www.liebertpub.com/jir

Mary Ann Liebert, Inc. is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Viral Immunology, AIDS Research and Human Retroviruses, and DNA and Cell Biology. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry's most widely read publication worldwide. A complete list of the firm's 70 journals, books, and newsmagazines is available at www.liebertpub.com

Mary Ann Liebert, Inc. 140 Huguenot St., New Rochelle, NY 10801-5215 www.liebertpub.com
Phone: (914) 740-2100 (800) M-LIEBERT Fax: (914) 740-2101


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2011-10/mali-nlb102711.php

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Nokia Lumia 800 shipping in November for $585, available for pre-order now

Nokia has just announced that its recently unveiled Lumia 800 will begin shipping in November to select markets, for around €420, or about $585. It'll roll out next month across France, Germany, Italy, the Netherlands, Spain and the UK, before making its way to Hong Kong, India, Russia, Singapore and Taiwan, by the close of 2011. The Lumia 710, meanwhile, is priced at €270 (around $376), and will be available in Hong Kong, India, Russia, Singapore and Taiwan by the end of this year. Early birds, however, can pre-order the Lumia 800 now -- just click the source link below for more details.

Nokia Lumia 800 shipping in November for $585, available for pre-order now originally appeared on Engadget on Wed, 26 Oct 2011 05:30:00 EDT. Please see our terms for use of feeds.

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Source: http://www.engadget.com/2011/10/26/nokia-lumia-800-shipping-in-november-for-585-available-for-pre/

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Savage Joplin tornado exposed lead contamination (Reuters)

KANSAS CITY, Mo (Reuters) ? The city of Joplin is asking the federal government to help clean up lead contamination on about 1,500 properties damaged in the savage May 22 tornado.

The twister tore apart structures that contained lead and disrupted soil on property built atop of old lead mines, Joplin city officials said in a letter to the Environmental Protection Agency.

Cleanup will cost an estimated $5,000 per property or roughly $7.5 million, said Mayor Mike Woolston and City Manager Mark Rohr in a letter early this month to EPA Regional Administrator Karl Brooks in Kansas City.

EPA spokesman David Bryan said Thursday that the agency is preparing a response and will work with the city to identify lead-contaminated sites and develop a cleanup plan.

"The agreement will include some type of funding mechanism," Bryan said.

The EF-5 tornado destroyed some 9,000 homes and other buildings in Joplin and took 162 lives. Some of the destroyed structures had basements, crawl spaces or slabs made of materials that included lead chat, used before its health risks were known, city officials said.

Much of Joplin is built on old mine sites. The EPA waged a cleanup effort in the early 1990s because of soils contaminated by lead and cadmium. Lead testing has for years been required prior to building projects, but the cost in the wake of the tornado exceeds the means of most residents, the city officials said.

"High lead levels in the disrupted soil potentially represent a significant liability issue for Joplin and a safety hazard for our community as well as a possible impediment to our rebuilding efforts...." Woolston and Rohr wrote.

The Jasper County Health Department recently tested a sampling of 43 properties for lead and cadmium in the affected area and found that 19 of them were in need of some level of remediation, documents show.

(Editing by Greg McCune)

Source: http://us.rd.yahoo.com/dailynews/rss/weather/*http%3A//news.yahoo.com/s/nm/20111027/us_nm/us_tornado_joplin_lead

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Thursday, October 27, 2011

Jets for iPhone: Find Out Where the Best Seat on the Plane Is [IPhone Apps]

I don't know when flying turned annoying for me but I absolutely hate it now. Going through security, dealing with checked bag fees and then getting stuck with an annoyingly terrible seat? Gah. Kill me. Jets doesn't solve most of my air travel woes but it does help me figure out what the best seat on the plane is. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/FOqvoQRBjSA/jets-for-iphone-find-out-where-the-best-seat-on-the-plane-is

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Wednesday, October 26, 2011

Government job losses a growing drag on recovery (AP)

WASHINGTON ? Conservative Republicans have long clamored for government downsizing. They're starting to get it ? by default.

Crippled by plunging tax revenues, state and local governments have shed over a half million jobs since the recession began in December 2007. And, after adding jobs early in the downturn, the federal government is now cutting them as well.

States cut 49,000 jobs over the past year and localities 210,000, according to an analysis of Labor Department statistics. There are 30,000 fewer federal workers now than a year ago ? including 5,300 Postal Service jobs canceled last month.

By contrast, private-sector jobs have increased by 1.6 million over the past 12 months. But the state, local and federal job losses have become a drag on efforts to nudge the nation's unemployment rate down from its painfully high 9.1 percent.

The economy has been expanding, at least modestly, since the middle of 2009. And state and local governments are usually engines of job growth during recoveries. But not now, said economist Heidi Shierholz of the labor-aligned Economic Policy Institute.

"The public sector didn't start to lose jobs right away. But then it did as the budget crunch really hit. State governments are not allowed to run deficits. So the private sector is expanding while the public sector is shedding jobs ? to the tune of 35,000 jobs a month," she said.

President Barack Obama sought to ease the crunch by including $35 billion to prevent layoffs of police, firefighters and teachers in his $447 billion jobs package. But that big bill hit a GOP wall in Congress.

Efforts to pass what Obama called "bite-sized pieces" of the big bill have stalled, too. Republicans don't want to swallow them, regardless the serving size. Senate Republicans blocked the $35 billion installment late last week when Democratic leaders called it up as stand-alone legislation.

The dynamic is already reverberating through the gathering presidential campaign cycle, with Republicans making an issue out what they depict as Obama's inability to turn the economy around. This has been driven home in every one of the frequent Republican presidential debates, and is certain to become even more intense as the GOP field narrows. The weak economy is a main factor in Obama's current approval ratings, the lowest of his presidency.

No sitting president since Franklin D. Roosevelt in 1936 and 1940 has been elected with the unemployment rate as high as it stands today ? hovering near or above 9 percent for more than two years. In 1936, the rate was 17 percent and in 1940, 15 percent, but then it was on a downward trend from over 24 percent earlier in the Great Depression.

Ronald Reagan's durable 1980 campaign slogan that government "is not the solution to our problem, government is the problem" is a cherished GOP refrain. Most recently, it's been echoed in tea party calls for smaller government.

Yet the federal bureaucracy grew by leaps and bounds during Reagan's eight years in office ? and under every Republican and Democratic president since.

Reagan-inspired conservative visions of smaller government are usually premised on deep spending cuts, low taxes, and program eliminations. All current GOP presidential contenders have subscribed to this line, as have GOP congressional leaders.

The recession-forced shrinkage of state, local and federal workforces ? even as the federal debt continues to swell ? is not exactly what tea party activists and other fiscal conservatives had in mind.

Cities and counties are hampered by lower property tax revenue because of collapsing real estate values. States are hurt by lower income and sales tax revenue because of the deep recession and stubborn unemployment.

The National Association of State Budget Officers says states were able to sustain spending growth through 2010 principally with federal stimulus money. But it has since dried up. The loss of the federal stimulus "combined with a slow recovery in state revenue collections will continue the tight resource environment for states in fiscal 2012," reports the association. Most state fiscal years begin in July.

Private business gains are too modest to significantly lower the unemployment rate, despite last week's claim by Senate Majority Leader Harry Reid that "private-sector jobs have been doing just fine."

Economists suggest roughly 200,000 new jobs a month ? or 2.4 million a year ? are needed to significantly lower the jobless rate. It takes from 100,000 to 150,000 new jobs a month just to tread water and match working-age population growth.

All told, since the recession began, local governments have bled 405,000 jobs, state governments 50,000. The federal government has added a net 63,000 jobs after subtracting the more recent losses.

Statistically, the recession ended in June 2009, but it's been a tough slog since for nearly everybody. One exception: The number of people earning $1 million a year or more increased in 2010 by nearly 20 percent, the government reported last week.

Efforts to spur job growth ? while also addressing chronic deficits ? have been snarled by adamant GOP refusal to raise taxes of any kind, and Democratic stands against trimming popular government health and retirement programs.

And more government job losses could be looming as the clock ticks down on Congress' deficit-cutting supercommittee. The panel, a product of last summer's debt-limit deal and comprising six lawmakers from each party, is tasked with delivering recommendations by Thanksgiving for $1.2 trillion in deficit reductions over the next decade.

If the panel fails to strike a deal that wins congressional approval by year's end, the $1.2 trillion would be triggered in indiscriminate across-the-board cuts beginning in January 2013. Defense jobs, here and on installations across the nation, would be particularly vulnerable to layoffs.

Of course, once the recovery runs its course ? and recoveries always have ? the jobless rate may well return to 5-6 percent. Consumer spending will be up again, and so will tax revenues for federal as well as state and local governments. And government hiring will probably resume. The big question is when.

Chris Edwards, tax policy director for the libertarian Cato Institute, said he doesn't believe helping state and local governments should be a federal financial responsibility. "They should tighten their belts," he said.

"Governments are not very good at manipulating the economy in the short run," Edwards added. "We haven't solved recessions yet. And I don't think governments will with activist policies."

But Rob Shapiro, a former undersecretary of commerce in the Clinton administration and now chairman of Sonecon, an economic consulting firm, sees things differently.

Cuts in spending and regulation don't encourage private job creation by making government more business friendly, as conservatives politicians contend, Shapiro said. They just mean more lost jobs upfront because government spending cuts almost always breed more layoffs.

"We need to give significant help to the states. Their revenues are down because the economy is weak. And that's forcing them to cut spending. And the spending they can cut the most easily is workers," Shapiro said.

Absent a federal helping hand, "the states will certainly continue to lose jobs," Shapiro said.

___

Follow Tom Raum on Twitter at http://twitter.com/tomraum

Source: http://us.rd.yahoo.com/dailynews/rss/topstories/*http%3A//news.yahoo.com/s/ap/20111025/ap_on_bi_ge/us_broken_budgets_shrinking_government

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Just in time for the holidays, a bad economic mood

FILE - In this Sept. 29, 2011 file photo, a woman and child leave a mall with purchases in Culver City, Calif. Consumers' confidence in the economy fell in October to the lowest it's been since 2009 when the U.S. was in the middle of a deep recession, according to a report released Tuesday, Oct. 25, 2011, by a private research group.(AP Photo/Reed Saxon, File)

FILE - In this Sept. 29, 2011 file photo, a woman and child leave a mall with purchases in Culver City, Calif. Consumers' confidence in the economy fell in October to the lowest it's been since 2009 when the U.S. was in the middle of a deep recession, according to a report released Tuesday, Oct. 25, 2011, by a private research group.(AP Photo/Reed Saxon, File)

(AP) ? Americans say they feel worse about the economy than they have since the depths of the Great Recession. And it's a bad time for a bad mood because households are starting to make their holiday budgets.

It might not be all doom and gloom, though. Sometimes what people say about the economy and how they behave are two different things.

Consumer confidence fell in October to the lowest since March 2009, reflecting the big hit that the stock market took this summer and frustration with an economic recovery that doesn't really feel like one.

The Conference Board, a private research group, said its index of consumer sentiment came in at 39.8, down about six points from September and seven shy of what economists were expecting.

The reading is still well above where the index stood two and a half years ago, at 26.9. But it's not even within shouting distance of 90, what it takes to signal that the economy is on solid footing.

Economists watch consumer confidence closely because consumer spending accounts for about 70 percent of U.S. economic activity. The index measures how shoppers feel about business conditions, the job market and the next six months.

It came exactly two months before Christmas, with retailers preparing for the holiday shopping season, their busiest. Almost twice as many people now expect a pay cut over the next six months as expect a raise.

"If people think their income is declining, they're not going to be inclined to spend," said Jacob Oubina, an economist at RBC Capital Markets.

Economists point out that consumer confidence is not as simple as a single number, though. The feelings people express about the economy do not always track how they actually spend money.

In September, for example, despite feeling bad about the economy, people increased their spending on retail goods by the most since March. More people bought new cars, a purchase people typically make when they are confident in their finances.

The percentage of Americans who plan to buy a major appliance in the next six months, such as a television or washing machine, rose to 46 percent, up from 41 percent. Exactly half plan to take a vacation in the next six months, up from 47 percent.

Marc Rosenberg, CEO of SkyBluePink Concepts, a toy marketing company, said he looks for broader trends in the monthly consumer confidence numbers but doesn't pay attention to the monthly changes.

"I think it is nice background music," he said.

It's still not a very happy tune. Jessica Jarmon was laid off from her job in social work in March. For the past three months, she has worked a temp job in the same industry, but that ended last week.

She has a job interview Wednesday morning, but she said it's hard to tell whether the economy is getting better or not.

"You hear about one company creating 16,000 jobs, and then you hear about another company laying off 10,000 jobs. Maybe, at best, we are just breaking even," said Jarmon, who lives in Philadelphia.

Mark Vitner, senior U.S. economist at Wells Fargo, said he will probably trim his forecast for holiday revenue in the retail industry based on Tuesday's figure.

Vitner said the persistent gloomy headlines about the economy may lead people to say they feel worse about things than their own situations would suggest. They might have a good job and stable finances, for example, but still report feeling sour.

But the decline in confidence is "too significant to get away from it," he said. "Consumers are losing hope that strong growth is around the corner."

Higher earners are also starting to lose confidence, a bad sign because they account for a disproportionate amount of spending. The confidence index for people making more than $50,000 has dropped six months in a row.

"The upper income brackets have weathered the recession and recovery better than most citizens, and declining confidence among this group is certainly unwelcome," Dan Greenhaus, an economist at the brokerage BTIG, said in a note to clients.

Consumer confidence had been recovering fitfully since hitting an all-time low of 25.3 in February 2009, but has taken a turn for the worse as Americans worry about high unemployment, rising prices for food and clothes and an overall weak economy.

The index is based on a survey conducted Oct. 1-13 of about 500 randomly selected people nationwide.

It was three days after the survey got under way, on Oct. 4, that the stock market began a remarkable rally. The Dow Jones industrial average gained 12 percent in three weeks, from the Oct. 3 close through Monday's trading.

The Dow fell almost 2 percent Tuesday, not just because of consumer confidence but because investors are worried about corporate earnings and about whether Europe can find a solution to its crippling debt problem.

The last time consumer confidence was this weak was also the turning point for the stock market in its severe downturn during the recession. It was in March 2009 that the Dow bottomed out at 6,547.

The survey found that a growing number of Americans are worried about making less money over the next six months. The proportion of people expecting a pay cut is about nine percentage points higher than those who expect a raise, the biggest gap since April 2009, Oubina said.

___

Rugaber reported from Washington. Associated Press Writer Joseph Pisani contributed to this report from New York.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2011-10-25-Consumer%20Confidence/id-a714d1d3401241b1911bff09023613aa

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Tuesday, October 25, 2011

Australia's 'Rogue' Man-Eating Sharks Actually Chasing Whales (LiveScience.com)

After the attack on an American diver by a great white shark off the coast of Australia, the rumor mill is swilling with talk of a "rogue man-eating shark" that developed a taste for humans, killing three men over the last two months.

The most recent attack happened on Saturday when a great white shark attacked and killed American diver George Thomas Wainwright. Two previous attacks on humans by great whites have occurred in the last two months, one killing an Australian swimmer on Oct. 10 and the other a body boarder who was lethally attacked on Sept. 4.?

Australian waters usually see about one fatal shark attack per year; but these waters are the primary home of the great white shark, a large species that can grow up to 20 feet (6 meters) long. Last year, 14 unprovoked shark attacks on humans were reported in Australia, only one of which was fatal.

Scientists say the recent attacks probably came from three separate sharks."There's whales moving by that coastline at this time of the year, and the white sharks follow," George Burgess, a researcher at the University of Florida and curator of the International Shark Attack File, which catalogs shark attacks around the world. "The chance of an individual shark being involved in all three of these incidences is astronomically low. They travel 40 to 50 miles a day." [Image Gallery: Great White Sharks]

Sharks gone rogue

Rogue sharks, typified by the shark in "Jaws," are thought to repeatedly attack humans, though such behavior is abnormal for sharks.

"The theory of a 'rogue' shark is unlikely, sometimes a single shark may be responsible for subsequent attacks done in the same area, in a clustered pattern," Fabio Hazin, a researcher at the Federal Rural University of Pernambuco in Brazil, told LiveScience in an email."This, however, tends to be more a consequence of the shark and human beings being close together than to a vicious nature of some shark specimens."

One example of such a rogue, the only that Burgess has seen in his 40 years of cataloging shark attacks, happened in Egypt last year. A ship of imported sheep from New Zealand headed to Egypt had been dropping their dead along the way. This lured a shark to the shore, where it attacked five people, killing one.

"That was a very different species and different ecological situation," Burgess told LiveScience. "It was a once in a lifetime experience for myself, after 40 years as a keeper of shark attacks."

A rogue white? Not so fast.

Australia's great whites are currently in the midst of their annual migration (they follow the whale migration paths up the western Australia coast), which would bring them into contact with humans. Three different sharks, following the same path up the coast and passing the same human-infested bathing and boating areas, are likely responsible for the recent attacks Burgess said.

"This is a very unlikely candidate for one to have stayed around and gotten the taste for humans, particularly in the case of the white shark, which is so highly migratory," Burgess said.

There were several possible reasons why shark attacks in the area might be higher than normal, Burgess said. It's possible that changes in climate may be shifting migration patterns, bringing sharks and humans closer together. Warmer temperatures would also bring more humans into the water. [10 Incredible Animal Migrations]

I'd rather win the lottery

Internationally, the number of shark fatalities is down, though the actual number of attacks is rising; shark attacks hit a global 10-year high in 2010 with 115 human-shark incidents that year. That increase is probably due to increased human presence in shark territory. Only six of these incidents ended in a dead human, though.

"We should always be cautious when entering into the sea, since it is an environment different from the one we live in," Hazin said. "We should not forget that drowning kills thousands and thousands more people every year than shark attacks."

The shark attacks in Australia have prompted calls to kill off any sharks in the area, which Premier Colin Barnett is said to be considering. Researchers are against such a shark hunt, since there is no way to know which shark or sharks are responsible for the human deaths without killing them and cutting open their stomachs.

"The region will be better off if the resources being given to hunt the killer shark would be used to study the situation ? and reduce the chances of it happening again," Burgess said. "The only answer we are going to find is if we scientifically study the situation carefully and understand better the movement patterns of the sharks."

You can follow LiveScience staff writer Jennifer Welsh on Twitter @microbelover. Follow LiveScience for the latest in science news and discoveries on Twitter @livescience and on Facebook.

Source: http://us.rd.yahoo.com/dailynews/rss/science/*http%3A//news.yahoo.com/s/livescience/20111024/sc_livescience/australiasroguemaneatingsharksactuallychasingwhales

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Bachmann brushes off idea she's given up on NH (AP)

WASHINGTON ? Republican presidential candidate Michele Bachmann is brushing off the idea that her campaign is all but giving up on winning the New Hampshire primary.

The Associated Press reported last week that an exodus in New Hampshire cost Bachmann her staff in the first-in-the-nation primary state.

The Minnesota congresswoman tells "Fox News Sunday" that she's replacing the New Hampshire staff and is focused on Iowa because its caucuses are scheduled Jan. 3, before the New Hampshire primary.

Bachmann has spent little time campaigning in New Hampshire, where her message as a social conservative has less appeal than in Iowa or in South Carolina, another state with an early primary.

Source: http://us.rd.yahoo.com/dailynews/rss/politics/*http%3A//news.yahoo.com/s/ap/20111023/ap_on_el_ge/us_bachmann

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